Losing just 5% to 10% of body weight with diet and exercise has proven to reduce the risk of cardiovascular disease in adult patients with obesity or overweight, but that’s not always possible. The FDA has approved weekly Semaglutide injections for chronic weight management in obese or overweight adults with at least one weight-related condition. This under-the-skin injection can help you lose up to two pounds per week when paired with a reduced-calorie diet and increased physical activity.